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Volume 15 Issue 2, February 2018

Cover image supplied by Oliver Soehnlein and Carlos Silvestre-Roig from the Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University, Munich, Germany. The picture shows an advanced atherosclerotic lesion in a hypercholesterolaemic mouse, with staining for macrophages, smooth muscle cells, nuclei, and endothelium.

Research Highlight

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In Brief

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Research Highlight

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Year in Review

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Review Article

  • This Review summarizes the latest findings on heart reverse remodelling, which demonstrate that despite apparent normalization of function, the molecular changes associated with heart failure persist in the reverse-remodelled heart. This myocardial remission is distinct from true recovery, in which both function and molecular makeup are normalized. These findings have implications for developing therapies to repair the failing heart.

    • Gene H. Kim
    • Nir Uriel
    • Daniel Burkhoff
    Review Article
  • Increased arterial stiffness influences pulse pressure, wave reflections, kidney function, and cardiovascular risk. In this Review, Safar describes the importance of arterial stiffness in the diagnosis and management of hypertension, using historical perspectives to emphasize the need for new treatment approaches in patients with essential hypertension.

    • Michel E. Safar
    Review Article
  • Cardiovascular mortality among the almost 600 million people living in the Eastern Mediterranean region (EMR) has been proposed to increase more dramatically in the next decade than in any other region except Africa. Turk-Adawi and colleagues summarize the available data on cardiovascular disease burden, risk factors, and treatment modalities for the EMR population.

    • Karam Turk-Adawi
    • Nizal Sarrafzadegan
    • Sherry L. Grace
    Review Article
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Correspondence

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Consensus Statement

  • A range of drugs is available for symptomatic angina, but the optimal choice or combination of therapies is often uncertain, and contemporary guidelines do not necessarily provide definite recommendations. In this Consensus Statement, Ferrari and colleagues propose an individualized approach to angina treatment, which takes into consideration the patient, their comorbidities, and the underlying mechanism of disease.

    • Roberto Ferrari
    • Paolo G. Camici
    • José L. Lopez-Sendon
    Consensus Statement Open Access
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