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Where do new endothelial cells come from in the injured heart?

Nature Reviews Cardiology volume 14, pages 507–508 (2017)Cite this article

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Revascularization of ischaemia-injured myocardium is critical for functional recovery. A new study shows that endothelial cells of neovessels in the injured heart derive from pre-existing endothelial cells. This new finding focuses research on therapeutic strategies to direct the neovasculature to deliver oxygen and nutrients effectively to the ischaemic myocardium.

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Figure 1: Myocardial neovascularization and repair.

References

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Acknowledgements

The authors acknowledge funding from March of Dimes (Gene Discovery & Translational Grant, 6-FY15-223 to D.M.G.) and NIH (R01HL125815 and R01HL133016 to D.M.G.; R01 EY025979-01 and R01HLI125811 to A.E.).

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Authors and Affiliations

  1. Daniel M. Greif is at the Cardiovascular Research Center and the Departments of Medicine and Genetics, 300 George Street, Yale University School of Medicine, New Haven, Connecticut 06510–3221, USA.,

    Daniel M. Greif

  2. Anne Eichmann is at the Cardiovascular Research Center and the Department of Cellular and Molecular Physiology, 300 George Street, Yale University School of Medicine, New Haven, Connecticut 06510–3221, USA,

    Anne Eichmann

  3. and at INSERM U970, Paris Cardiovascular Research Center, 56 Rue Leblanc, 75015 Paris, France.,

    Anne Eichmann

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  1. Daniel M. Greif
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Correspondence to Daniel M. Greif or Anne Eichmann.

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The authors declare no competing financial interests.

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Greif, D., Eichmann, A. Where do new endothelial cells come from in the injured heart?. Nat Rev Cardiol 14, 507–508 (2017). https://doi.org/10.1038/nrcardio.2017.121

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