Public-access defibrillation is known to improve survival rate in out-of-hospital cardiac arrest, but evidence on a population level is currently lacking. In a Japanese registry study involving 43,762 patients with ventricular fibrillation cardiac arrest, 1-month survival with a favourable neurological outcome was 38.5% in individuals who received public-access defibrillation, and 18.2% in individuals who did not (adjusted OR 2.03, 95% CI 1.87–2.20). Furthermore, the estimated number of survivors with a favourable neurological outcome attributable to public-access defibrillation increased from six in 2005 to 201 in 2013 (P <0.001).