Individuals with low (≤30 mg/dl) levels of high-density lipoprotein cholesterol (HDL-C), have higher cardiovascular and noncardiovascular mortality than individuals with intermediate levels of HDL-C. However, individuals with high levels of HDL-C (>70 mg/dl in men; >90 mg/dl in women) also have increased noncardiovascular morality. These findings come from an analysis of 631,762 individuals without previous cardiovascular conditions or severe comorbidities in the CANHEART cohort. “HDL-C level is a marker of poor general health and may not be an independent modifiable risk factor specifically for cardiovascular disease,” summarize the investigators.