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Coronary artery disease

Sex-related differences in CAD and plaque characteristics

Sex has an important role in the diagnosis of coronary artery disease (CAD). Results from the PROMISE trial highlight the influence of sex on presentation characteristics, diagnostic testing, and subsequent cardiac events among patients with suspected CAD. Differences in plaque characteristics among patients with stable CAD have also been suggested.

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Acknowledgements

J.K.M. is supported by grants from the National Institutes of Health (NIH/NIHLBI R01HL111141, NIH/NIHLBI R01HL115150, NIH/NIHLBI R01HL118019, NIH/NIHLBI U01HL105907) and from the Qatar National Research Foundation (NPRP09-370-3-089).

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Correspondence to Jessica M. Peña.

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J.K.M. serves as a consultant to GE Healthcare and HeartFlow Inc.; is on the medical advisory board of Arineta; retains ownership in Autoplaq and MDDX; and has a research agreement with GE Healthcare. J.M.P. declares no competing interests.

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Peña, J., Min, J. Sex-related differences in CAD and plaque characteristics. Nat Rev Cardiol 13, 318–319 (2016). https://doi.org/10.1038/nrcardio.2016.75

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