Hypoxia and metabolism
Throughout 2008, a series of specially commissioned articles that examine hypoxia and metabolism in tumour biology will be published in Nature Reviews Cancer. Although hypoxia is not a new phenomenon, we now have a much greater understanding of the molecular links between hypoxic conditions and tumour development. Apart from driving angiogenesis, hypoxia is also linked with changes in cellular metabolism, an area that has become a hot topic in cancer research. A greater understanding of these closely related tumorigenic changes should prove fruitful in the pursuit of more effective cancer drugs.
2008
March 2008 Vol 8 No 3
Hypoxia, DNA repair and genetic instability
Robert G. Bristow & Richard P. Hill
doi:10.1038/nrc2344
January 2008 Vol 8 No 1
A microenvironmental model of carcinogenesis
Robert A. Gatenby & Robert J. Gillies
doi:10.1038/nrc2255
January 2008 Vol 8 No 1
The interplay between MYC and HIF in cancer
Chi V. Dang, Jung-whan Kim, Ping Gao & Jason Yustein
doi:10.1038/nrc2274