Epigenetics and genetics
The deregulated expression of genes and non–protein coding RNAs, which occur through both genetic mechanisms (such as mutation and translocation) and epigenetic mechanisms (such as promoter methylation and histone modifications) are known to promote tumorigenesis and tumour progression. Our knowledge of the mechanisms through which such changes occur and the resulting effects on tumour biology and clinical outcome is increasing rapidly. This series of articles highlights this recent progress and discusses the implications for cancer diagnosis and treatment.
Index
2013
July 2013 Vol 13 No 7
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
Winston Timp & Andrew P. Feinberg
doi:10.1038/nrc3486
2012
September 2012 Vol 12 No 9
The role of mutations in epigenetic regulators in myeloid malignancies
Alan H. Shih, Omar Abdel-Wahab, Jay P. Patel & Ross L. Levine
doi:10.1038/nrc3343
July 2012 Vol 12 No 7
Developmental reprogramming of cancer susceptibility
Cheryl Lyn Walker & Shuk-mei Ho
doi:10.1038/nrc3220
2011
December 2011 Vol 11 No 12
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
Andrea L. Kasinski & Frank J. Slack
doi:10.1038/nrc3166
September 2011 Vol 11 No 9
MicroRNA regulation by RNA-binding proteins and its implications for cancer
Marieke van Kouwenhove, Martijn Kedde & Reuven Agami
doi:10.1038/nrc3107
Advance online publication (July 2011)
Cancer biology and NuRD: a multifaceted chromatin remodelling complex
Anne Y. Lai & Paul A. Wade
doi:10.1038/nrc3091
July 2011 Vol 11 No 7
SWI/SNF nucleosome remodellers and cancer
Boris G. Wilson & Charles W. M. Roberts
doi:10.1038/nrc3068
2010
October 2010 Vol 10 No 10
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins
Alea A. Mills
doi:10.1038/nrc2915
October 2010 Vol 10 No 10
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis
Man Mohan, Chengqi Lin, Erin Guest & Ali Shilatifard
doi:10.1038/nrc2915
July 2010 Vol 10 No 7
Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers
Ping Chi, C. David Allis & Gang Greg Wang
doi:10.1038/nrc2876
May 2010 Vol 10 No 5
Architecture of inherited susceptibility to common cancer
Olivia Fletcher & Richard S. Houlston
doi:10.1038/nrc2840
January 2010 Vol 10 No 1
Leukaemogenesis: more than mutant genes
Jianjun Chen, Olatoyosi Odenike & Janet D. Rowley
doi:10.1038/nrc2765
January 2010 Vol 10 No 1
A census of amplified and overexpressed human cancer genes
Thomas Santarius, Janet Shipley, Daniel Brewer, Michael R. Stratton & Colin S. Cooper
doi:10.1038/nrc2771
2009
November 2009 Vol 9 No 11
Polycomb group proteins: navigators of lineage pathways led astray in cancer
Adrian P. Bracken & Kristian Helin
doi:10.1038/nrc2736
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