Epigenetics and genetics
The deregulated expression of genes and non–protein coding RNAs, which occur through both genetic mechanisms (such as mutation and translocation) and epigenetic mechanisms (such as promoter methylation and histone modifications) are known to promote tumorigenesis and tumour progression. Our knowledge of the mechanisms through which such changes occur and the resulting effects on tumour biology and clinical outcome is increasing rapidly. This series of articles highlights this recent progress and discusses the implications for cancer diagnosis and treatment.
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2009
November 2009 Vol 9 No 11
Polycomb group proteins: navigators of lineage pathways led astray in cancer
Adrian P. Bracken & Kristian Helin
doi:10.1038/nrc2736
