Advance online publication
The latest articles are published online ahead of print (AOP) on a weekly basis. These online versions are definitive and may be cited using the digital object identifier (DOI).
Article Types
Review
Article series: MYC
The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
Tracy A. Brooks & Laurence H. Hurley
Published online: 12 November 2009 | doi:10.1038/nrc2733
Transcription-induced DNA supercoiling has dynamic effects on the MYC promoter element: it converts duplex DNA to non-duplex DNA structures. These non-duplex DNA structures regulate transcription and are amenable to small-molecule targeting. Does this represent another opportunity for the treatment of tumours?
Perspectives
Opinion
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
Sharad Kumar
Published online: 05 November 2009 | doi:10.1038/nrc2745
Recent evidence suggests that caspase 2 may have multiple roles in the response to DNA damage, cell cycle regulation and tumour suppression. These findings are unexpected and have important implications for our understanding of tumorigenesis and the treatment of cancer.
About AOP
Until print versions of AOP papers are published, they should be cited in the style "Nature Reviews Cancer AOP, published online day month year; doi:10.1038/nrcXXX". Once the print version (identical to the AOP) is published, it should be cited as follows: "Nature Reviews Cancer volume number, page range (year); doi:10.1038/nrcXXX".
