Perspectives
Nature Reviews Cancer 9, 665-674 (September 2009) | doi:10.1038/nrc2714
Article series: Therapeutic resistance
Opinion: Environment-mediated drug resistance: a major contributor to minimal residual disease
Mark B. Meads1, Robert A. Gatenby2 & William S. Dalton1 About the authors
Abstract
Environment-mediated drug resistance is a form of de novo drug resistance that protects tumour cells from the initial effects of diverse therapies. Surviving foci of residual disease can then develop complex and permanent acquired resistance in response to the selective pressure of therapy. Recent evidence indicates that environment-mediated drug resistance arises from an adaptive, reciprocal signalling dialogue between tumour cells and the surrounding microenvironment. We propose that new therapeutic strategies targeting this interaction should be applied during initial treatment to prevent the emergence of acquired resistance.
Author affiliations
- Mark B. Meads and William S. Dalton are at the Department of Experimental Therapeutics and Oncologic Sciences, H. Lee Moffitt Cancer Center, Florida 33612, USA.
- Robert A. Gatenby is at the Department of Radiology and Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center, Florida 33612, USA.
Correspondence to: William S. Dalton1 Email: william.dalton@moffitt.org
Published online 20 August 2009
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