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Research Highlights

Nature Reviews Cancer 9, 458–459 (1 July 2009) | doi:10.1038/nrc2686

Drug resistance: Getting through

Nicola McCarthy

Patients with pancreatic ductal adenocarcinoma (PDA) have a poor prognosis owing to several factors that include a poor response to chemotherapy. This is strange given that pancreatic tumour cells in vitro and mice with pancreatic cancer xenografts respond to the standard chemotherapeutic gemcitabine.