Perspectives
Nature Reviews Cancer 9, 501-507 (July 2009) | doi:10.1038/nrc2663
Timeline: Apoptosis and cancer: the genesis of a research field
Thomas G. Cotter1 About the author
Abstract
In multicellular organisms, the total number of cells is a balance between the cell-generating effects of mitosis and cell death that is induced through apoptosis. A disruption of this delicate balance can lead to the development of cancer. This Timeline article focuses on how the field of apoptosis biology has developed in the context of its contribution to our understanding of cell death, or lack of it, in the development of malignant disease. It traces the course of research from key discoveries in fundamental biology to potential therapeutic applications.
Author affiliations
- Thomas G. Cotter is at the Tumour Biology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland.
Correspondence to: Thomas G. Cotter1 Email: t.cotter@ucc.ie
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