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Emerging evidence points to a crucial role for secreted factors in oncogene-induced cellular senescence and indicates possible cross-talk between senescent cells and their microenvironment. How are such signals integrated and what are the implications of this unexpected finding?
There are >200 naturally occurring single nucleotide polymorphisms (SNPs) ofTP53in human populations and only a fraction, if any, are expected to perturb p53 function. This Review discusses the evidence linking p53 SNPs with cancer risk and prognosis.
It is often forgotten that cells within tissues are continuously exposed to physical forces to which they respond by exerting reciprocal cell-generated force. This Review examines why the changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis.
The function of protein deacetylase SIRT1 in cancer is controversial: it has been shown to have oncogenic properties as well as tumour suppressor activity. How might these opposing functions be explained?
Which breast tumours does the term 'basal-like' best describe? In this Perspective the author argues that this term is misleading and explains why by use of current understanding of breast cancer pathology.
Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to characterize genetic profiles that predict patient response to radiotherapy.
