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Research Highlights
Nature Reviews Cancer 9, 769 (1 November 2009) | doi:10.1038/nrc2755
Hypoxia: HIF1 in opposition
Abstract
Constitutive expression of the hypoxia inducible factor 1 (HIF1) complex is most often associated with tumour progression and poor clinical outcome. However, expression of HIF1 is also evident during tumour suppression, and new results indicate that this might be the result of HIF1 regulation of the microRNA gene mir-210.
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