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Research Highlights
Nature Reviews Cancer 9, 766–767 (1 November 2009) | doi:10.1038/nrc2752
MicroRNA: Stage-specific signatures
Abstract
Do microRNA (miRNA) expression profiles reflect specific stages in tumour progression? Douglas Hanahan and colleagues set out to answer this question by analysing the miRNA transcriptome in distinct stages of tumorigenesis in the RIP1-Tag2 mouse model of pancreatic neuroendocrine tumours (PNETs). Normal, hyperplastic and angiogenic islets, primary tumours and liver metastases from RIP1-Tag2 mice were profiled for expression of all known mouse miRNAs, and this revealed that each stage had specific differences in miRNA expression.
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