Perspectives
Nature Reviews Cancer 9, 831-841 (November 2009) | doi:10.1038/nrc2731
Corrected online: 01 October 2009
Focus on: p53 - 30 years on
Timeline: 20 years studying p53 functions in genetically engineered mice
Lawrence A. Donehower1 & Guillermina Lozano2 About the authors
Abstract
Cell and molecular biological studies of p53 functions over the past 30 years have been complemented in the past 20 years by studies that use genetically engineered mice. As expected, mice that have mutant Trp53 alleles usually develop cancers of various types more rapidly than their counterparts that have wild-type Trp53 genes. These mouse studies have been instrumental in providing important new insights into p53 tumour suppressor function. Such studies have been facilitated by the development of increasingly sophisticated genetic engineering approaches, which allow the more precise manipulation of p53 structure and function in a mammalian model.
Author affiliations
- Lawrence A. Donehower is at the Departments of Molecular Virology and Microbiology, Molecular and Cellular Biology, and Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.
- Guillermina Lozano is at the Department of Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Correspondence to: Lawrence A. Donehower1Guillermina Lozano2 Email: larryd@bcm.edu; Email: gglozano@mdanderson.org
Published online 24 September 2009
* In the version of this article initially published online, in page 8, the sentence "For example, mammary gland–specific Wap1 (also known as Wfdc5)–Cre mice" was incorrect and should be "For example, mammary gland–specific Wap–Cre mice". This error has been corrected for the print, HTML and PDF versions of the article.
