Table of contents
January 2009 Vol 9 No 1
From the editors
p1 | doi:10.1038/nrc2581
Research Highlights
Metastasis: Moved to act | PDF (195 KB)
p3 | doi:10.1038/nrc2564
Oncogenesis: It's all about translation | PDF (173 KB)
p4 | doi:10.1038/nrc2565
Tumorigenesis: Can you have too much MYC? | PDF (164 KB)
p4 | doi:10.1038/nrc2578
Tumorigenesis: An end to the unSIRTainty? | PDF (217 KB)
p5 | doi:10.1038/nrc2569
Cancer stem cells: Common as muck | PDF (209 KB)
p6 | doi:10.1038/nrc2563
Metastasis: Maintaining group polarity | PDF (346 KB)
p6 | doi:10.1038/nrc2573
In brief
Microrna | Tumorigenesis | Leukaemia | Tumour suppressors | PDF (125 KB)
p7 | doi:10.1038/nrc2574
Proteomics: Insider information | PDF (184 KB)
p8 | doi:10.1038/nrc2567
Biomarkers: Decoding the microvesicle message | PDF (186 KB)
p8 | doi:10.1038/nrc2572
In the news
The regression question | PDF (89 KB)
p8 | doi:10.1038/nrc2575
Technology Watch
Improving cancer cell imaging | PDF (117 KB)
p9 | doi:10.1038/nrc2580
Angiogenesis: Renaissance molecule | PDF (251 KB)
p10 | doi:10.1038/nrc2568
Cell polarity: Morphogenesis is the key | PDF (188 KB)
p10 | doi:10.1038/nrc2576
Genomics: Distinguishing drivers from passengers | PDF (187 KB)
p11 | doi:10.1038/nrc2566
Signalling: ERBB2 hangs in the balance | PDF (177 KB)
p12 | doi:10.1038/nrc2570
Cytoskeleton: Invading forces | PDF (178 KB)
p12 | doi:10.1038/nrc2579
Metabolism: Room to breathe | PDF (190 KB)
p13 | doi:10.1038/nrc2577
Reviews
The biology of Hodgkin's lymphoma
Ralf Küppers
p15 | doi:10.1038/nrc2542
Hodgkin's lymphoma is a unique B-cell malignancy. This Review discusses the aetiology and genetics of this disease and its distinguishing features.
Targeting cancer with small molecule kinase inhibitors
Jianming Zhang, Priscilla L. Yang & Nathanael S. Gray
p28 | doi:10.1038/nrc2559
Inhibition of kinase activity has received enormous interest as a therapeutic strategy for cancer. This Review discusses the current approaches to develop and characterize new inhibitors.
Tetraspanins: push and pull in suppressing and promoting metastasis
Margot Zöller
p40 | doi:10.1038/nrc2543
Tetraspanins have only recently received attention as both metastasis suppressors and metastasis promoters. The ability of these proteins to collect a variety of molecules associated with tumour progression or tumour suppression in membrane microdomains might explain their multifaceted functions in metastasis.
Perspectives
Opinion
Toll-like receptors and cancer
Seth Rakoff-Nahoum & Ruslan Medzhitov
p57 | doi:10.1038/nrc2541
The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. This Perspective discusses how the function of the Toll-like receptors may relate to these processes in the context of carcinogenesis.
Opinion
Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer
David H. Kirn & Steve H. Thorne
p64 | doi:10.1038/nrc2545
A new therapeutic class of oncolytic poxviruses has recently been developed that combines targeted and armed approaches for treating cancer. Using vaccinia virus as an example, this Perspective describes their mechanisms of action and promising clinical results.
