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Inhibition of kinase activity has received enormous interest as a therapeutic strategy for cancer. This Review discusses the current approaches to develop and characterize new inhibitors.
Tetraspanins have only recently received attention as both metastasis suppressors and metastasis promoters. The ability of these proteins to collect a variety of molecules associated with tumour progression or tumour suppression in membrane microdomains might explain their multifaceted functions in metastasis.
The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. This Perspective discusses how the function of the Toll-like receptors may relate to these processes in the context of carcinogenesis.
A new therapeutic class of oncolytic poxviruses has recently been developed that combines targeted and armed approaches for treating cancer. Using vaccinia virus as an example, this Perspective describes their mechanisms of action and promising clinical results.
