Table of contents
From the editors
p655 | doi:10.1038/nrc2498
Research Highlights
Tumorigenesis: Two-faced | PDF (125 KB)
p657 | doi:10.1038/nrc2469
Oncogenesis: Fusion protein guided by Sat Nav | PDF (134 KB)
p658 | doi:10.1038/nrc2473
Leukaemia: Preparation is everything | PDF (132 KB)
p658 | doi:10.1038/nrc2475
In the news
Costly cancer care | PDF (101 KB)
p658 | doi:10.1038/nrc2478
Biomarkers: Finding the needle in the haystack | PDF (160 KB)
p659 | doi:10.1038/nrc2474
Angiogenesis: VEGFR3 joins the crew | PDF (167 KB)
p660 | doi:10.1038/nrc2446
Tumour suppression: Sharing the limelight | PDF (170 KB)
p660 | doi:10.1038/nrc2470
Trial Watch
Still Sensitive? | Genetically more efficient | PDF (118 KB)
p661 | doi:10.1038/nrc2479
Translation: Interpreting p53 | PDF (151 KB)
p662 | doi:10.1038/nrc2471
Tumorigenesis: Marching to a different drum | PDF (159 KB)
p662 | doi:10.1038/nrc2472
Migration: RAB goes back to RAC | PDF (144 KB)
p662 | doi:10.1038/nrc2476
In brief
Tumorigenesis | Signalling | Cancer stem cells | PDF (144 KB)
p663 | doi:10.1038/nrc2477
Progress
Structural comparisons of class I phosphoinositide 3-kinases
L. Mario Amzel, Chuan-Hsiang Huang, Diana Mandelker, Christoph Lengauer, Sandra B. Gabelli & Bert Vogelstein
p665 | doi:10.1038/nrc2443
The recent determination of the structure of the class I phosphoinositide 3-kinase PI3K
has identified important structural differences between the class 1 PI3Ks. How can this information be used to improve cancer therapy?
Reviews
Article series: RB and E2F
Cellular mechanisms of tumour suppression by the retinoblastoma gene
Deborah L. Burkhart & Julien Sage
p671 | doi:10.1038/nrc2399
Data from human and mouse tumours indicate that loss of the tumour suppressor gene retinoblastoma (RB) contributes to both cancer initiation and progression. However, there is much we still need to learn about RB function and the consequences of its loss.
A new MAFia in cancer
Alain Eychène, Nathalie Rocques & Celio Pouponnot
p683 | doi:10.1038/nrc2460
Recent data support an important role for the large Maf proteins in cancer. This Review discusses the contribution of large Maf family members to oncogenesis.
Diet and cancer prevention: the roles of observation and experimentation
María Elena Martínez, James R. Marshall & Edward Giovannucci
p694 | doi:10.1038/nrc2441
The evaluation of dietary factors for cancer prevention through observational epidemiology and experimentation by randomized controlled trials (RCTs) has given inconsistent and sometimes opposing conclusions. Which study design is most appropriate?
Perspectives
Article series: Hypoxia and metabolism
Opinion
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Nicholas C. Denko
p705 | doi:10.1038/nrc2468
Aerobic glycolysis, or the 'Warburg effect', is a metabolic switch unique to tumour cells. But how might this change in tumour cell metabolism confer a growth advantage?
Article series: RB and E2F
Opinion
Tailoring to RB: tumour suppressor status and therapeutic response
Erik S. Knudsen & Karen E. Knudsen
p714 | doi:10.1038/nrc2401
Although RB was first identified as a tumour suppressor over 20 years ago, the implications of RB loss for tumour biology remain enigmatic. This Perspective discusses how context-specific consequences of RB inactivation might influence the response of a tumour to a range of therapeutic agents.
Innovation
Optical imaging for cervical cancer detection: solutions for a continuing global problem
Nadhi Thekkek & Rebecca Richards-Kortum
p725 | doi:10.1038/nrc2462
Cervical cancer is the leading cause of cancer death for women in developing countries. This Perspective discusses how recent advances in optical technologies can improve the accuracy and availability of cervical cancer screening.
Corrigendum: The challenge of cancer control in Africa
Rebecca J. Lingwood, Peter Boyle, Alan Milburn, Twalib Ngoma, John Arbuthnott, Ruth McCaffrey, Stewart H. Kerr & David J. Kerr
p732 | doi:10.1038/nrc2464
