Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Research Highlights
Nature Reviews Cancer 8, 662–663 (1 September 2008) | doi:10.1038/nrc2471
Translation: Interpreting p53
Abstract
Heterozygous mutations in the genes encoding ribosomal proteins (RPs) are emerging as important determinants of human disease and tumorigenesis. But what links Rp gene dosage and disease? In zebrafish, heterozygous loss of one of 17 of the 28 Rp genes results in the development of malignant peripheral nerve sheath tumours (MPNSTs), and zebrafish expressing a loss-of-function p53 protein also develop MPNSTs.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
