TABLE 1 | HIF1 targets that regulate glucose metabolism
From the following article:
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Nicholas C. Denko
Nature Reviews Cancer 8, 705-713 (September 2008)
doi:10.1038/nrc2468
| Product(s) of HIF1 target gene(s) | Metabolic function | Refs |
|---|---|---|
| Glucose transporters GLUT1 and GLUT3 | Glucose entry into the cell | 49,119 |
| HK2 | Phosphorylation of glucose | 53 |
| PGI, PFK1, aldolase, TPI, GAPDH, PGK, PGM, enolase, PK, PFKFB1–4 | Glycolysis | 7,120,121,122 |
| LDHA | Conversion of pyruvate to lactate | 58 |
| MCT4 | Removal of lactate from the cell | 59 |
| PDK1, MXI1 | Decreased mitochondrial activity | 11,12,13 |
| COX4I2, LON protease | Increased O2 consumption in hypoxia | 66 |
| COX4I2, cytochrome oxidase isoform 2; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GLUT, glucose transporter; HIF, hypoxia-inducible factor; HK, hexokinase; LDHA, lactate dehydrogenase A; MCT, monocarboxylate trasporter; MXI, max interactor; PDK, pyruvate dehydrogenase kinase; PFK, phosphofructokinase; PFKFB, 6-phospho-2-kinase/fructose 2,6 bisphosphatase; PGK, phosphoglycerate kinase; PGI, phosphoglucose isomerase; PGM, phosphoglycerate mutase; PK, pyruvate kinase; TPI, triosephosphate isomerase. | ||
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