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Nature Reviews Cancer 8, 665–669 (1 September 2008) | doi:10.1038/nrc2443

Structural comparisons of class I phosphoinositide 3-kinases

L. Mario Amzel , Chuan-Hsiang Huang , Diana Mandelker , Christoph Lengauer , Sandra B. Gabelli & Bert Vogelstein

Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate cell growth. One of these kinases, PI3Kα, is frequently mutated in diverse tumour types. The recently determined structure of PI3Kα reveals features that distinguish this enzyme from related lipid kinases. In addition, wild-type PI3Kγ differs from PI3Kα by a substitution identical to a PI3Kα oncogenic mutant (His1047Arg) that might explain the differences in the enzymatic activities of the normal and mutant PI3Kα. Comparison of the PI3K structures also identified structural features that could potentially be exploited for the design of isoform-specific inhibitors.