Review
Nature Reviews Cancer 8, 683-693 (September 2008) | doi:10.1038/nrc2460
A new MAFia in cancer
Alain Eychène1, Nathalie Rocques1 & Celio Pouponnot1 About the authors
Abstract
Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer — overexpression of the large Maf genes promotes the development of multiple myeloma — they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.
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Author affiliations
- Institut Curie, Centre de Recherche, Orsay F-91405 France and CNRS, UMR 146, Orsay F-91405 France.
Correspondence to: Celio Pouponnot1 Email: celio.pouponnot@curie.u-psud.fr
Published online 14 August 2008
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