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Research Highlights
Nature Reviews Cancer 8, 567 (1 August 2008) | doi:10.1038/nrc2463
Angiogenesis: A less bitter pill
Abstract
The broad-spectrum angiogenesis inhibitor TNP-470 is a potent suppressor of tumour growth and metastasis, but its use is limited because it requires lengthy bouts of parenteral administration. To remove this limitation, Folkman and colleagues have enclosed TNP-470 in nanopolymeric micelles and shown that in mice it retains the potency of the free drug.
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