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Nature Reviews Cancer 8, 572–573 (1 August 2008) | doi:10.1038/nrc2450

Angiogenesis: Turning it down a Notch

Safia Ali Danovi

The resistance of several tumour types to vascular endothelial growth factor (VEGF) inhibition has prompted the hunt for alternative molecular targets in the angiogenic cascade. A recent study confirms the NOTCH1 receptor as one such target.