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Nature Reviews Cancer 8, 569 (1 August 2008) | doi:10.1038/nrc2452

Angiogenesis: Survival of the infected

Katharine H. Wrighton

The development of Kaposi sarcoma, a highly vascular tumour of endothelial cell origin, is associated with a herpes virus, KSHV (Kaposi sarcoma-associated herpesvirus). Individual KSHV genes have been shown to upregulate the phosphoinositide 3-kinase (PI3K)–Akt–mammalian target of rapamycin (mTOR, also known as FRAP1) pathway.