Table of contents
From the editors
p405 | doi:10.1038/nrc2417
Research Highlights
Leukaemia: A provoking end? | PDF (338 KB)
p407 | doi:10.1038/nrc2412
Oncogenesis: A sideways move? | PDF (212 KB)
p408 | doi:10.1038/nrc2405
Imaging: Early detection for pancreatic cancer | PDF (189 KB)
p408 | doi:10.1038/nrc2407
Trial Watch
Prickly promise | PDF (85 KB)
p408 | doi:10.1038/nrc2416
Metastasis: Trading in mitochondria | PDF (347 KB)
p409 | doi:10.1038/nrc2411
Microenvironment: What do your surroundings mean? | PDF (446 KB)
p410 | doi:10.1038/nrc2409
Metastasis: Which way to the lungs? | PDF (225 KB)
p410 | doi:10.1038/nrc2410
In the news
Ensuring a good collection | PDF (74 KB)
p410 | doi:10.1038/nrc2415
In brief
Metabolism | Angiogenesis | Non-coding RNAS | PDF (95 KB)
p411 | doi:10.1038/nrc2414
Therapy: Reversed protection | PDF (170 KB)
p412 | doi:10.1038/nrc2406
Cell polarity: APC throws the anchor | PDF (426 KB)
p412 | doi:10.1038/nrc2413
Cell signalling: Dynamic redistribution | PDF (417 KB)
p413 | doi:10.1038/nrc2408
Reviews
Colonic crypt organization and tumorigenesis
Adam Humphries & Nicholas A. Wright
p415 | doi:10.1038/nrc2392
Recent advances in our understanding of intestinal crypt biology, including how mutations in stem cells become fixed and expand within the epithelium, has led to new theories on the origins of colonic adenomas and cancers.
Article series: Hypoxia and metabolism
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Mark W. Dewhirst, Yiting Cao & Benjamin Moeller
p425 | doi:10.1038/nrc2397
Hypoxia and free radicals, such as reactive oxygen and nitrogen species, alter the activity of the transcription factor HIF1, which can regulate tumour cell survival and angiogenesis. Intratumoural heterogeneity of these factors significantly affects HIF1 and consequently the response to cytotoxic therapy.
Deregulated proteolysis by the F-box proteins SKP2 and 
-TrCP: tipping the scales of cancer
David Frescas & Michele Pagano
p438 | doi:10.1038/nrc2396
Cell cycle progression is regulated by phosphorylation and protein degradation, which is mediated by ubiquitin ligases. This Review explores the relevance of two ubiquitin ligase specificity factors (F-box proteins) that are emerging as important players in tumour development.
Article series: Senescence
Telomere dysfunction and tumour suppression: the senescence connection
Yibin Deng, Suzanne S. Chan & Sandy Chang
p450 | doi:10.1038/nrc2393
Using recent evidence from mouse models, this Review discusses whether p53-dependent senescence induced by dysfunctional telomeres is as potent as apoptosis in suppressing tumorigenesis in vivo.
Perspectives
Innovation
The Mouse Tumor Biology database
Debra M. Krupke, Dale A. Begley, John P. Sundberg, Carol J. Bult & Janan T. Eppig
p459 | doi:10.1038/nrc2390
The Mouse Tumor Biology database seeks to facilitate the researcher's access to the ever increasing amount of data now being published using mouse models of cancer. Why is this database important and how does it relate to similar databases within the cancer research community?
Science and society
Heavy ion carcinogenesis and human space exploration
Marco Durante & Francis A. Cucinotta
p465 | doi:10.1038/nrc2391
The next generation of space missions will involve much longer exposures of astronauts to space radiation. Predicting what this means for cancer risk is a crucial but difficult task.
Timeline
Paul Ehrlich's magic bullet concept: 100 years of progress
Klaus Strebhardt & Axel Ullrich
p473 | doi:10.1038/nrc2394
One hundred years ago, Paul Ehrlich received the Nobel Prize for Physiology or Medicine. His idea of creating 'magic bullets' for use in the fight against human diseases has inspired generations of scientists to devise powerful molecular cancer therapeutics.
