Review
Nature Reviews Cancer 8, 415-424 (June 2008) | doi:10.1038/nrc2392
Colonic crypt organization and tumorigenesis
Adam Humphries1 & Nicholas A. Wright1 About the authors
Abstract
An appreciation of colonic crypt organization has become essential to any understanding of tumorigenesis in the colon. Intestinal crypts house tissue-specific, multipotential stem cells, which are located in the niche at the base of the intestinal crypt and are capable of regenerating all intestinal cell types. Recent advances in our understanding of crypt biology, including how mutations in stem cells become fixed and expand within the epithelium, has led to new theories on the origins of colonic adenomas and cancers.
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Author affiliations
- Histopathology Lab, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Correspondence to: Adam Humphries1 Email: Adam.Humphries@cancer.org.uk
Published online 15 May 2008
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