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Recent advances in our understanding of intestinal crypt biology, including how mutations in stem cells become fixed and expand within the epithelium, has led to new theories on the origins of colonic adenomas and cancers.
Hypoxia and free radicals, such as reactive oxygen and nitrogen species, alter the activity of the transcription factor HIF1, which can regulate tumour cell survival and angiogenesis. Intratumoural heterogeneity of these factors significantly affects HIF1 and consequently the response to cytotoxic therapy.
Cell cycle progression is regulated by phosphorylation and protein degradation, which is mediated by ubiquitin ligases. This Review explores the relevance of two ubiquitin ligase specificity factors (F-box proteins) that are emerging as important players in tumour development.
Using recent evidence from mouse models, this Review discusses whether p53-dependent senescence induced by dysfunctional telomeres is as potent as apoptosis in suppressing tumorigenesisin vivo.
The Mouse Tumor Biology database seeks to facilitate the researcher's access to the ever increasing amount of data now being published using mouse models of cancer. Why is this database important and how does it relate to similar databases within the cancer research community?
The next generation of space missions will involve much longer exposures of astronauts to space radiation. Predicting what this means for cancer risk is a crucial but difficult task.
One hundred years ago, Paul Ehrlich received the Nobel Prize for Physiology or Medicine. His idea of creating 'magic bullets' for use in the fight against human diseases has inspired generations of scientists to devise powerful molecular cancer therapeutics.
