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Research Highlights
Nature Reviews Cancer 8, 327 (1 May 2008) | doi:10.1038/nrc2378
Signalling: An oncogene becomes RESTless
Abstract
REST (repressor-element-1 silencing transcription factor) is a transcriptional repressor that is associated with the maintainenance of neuron stem cell self-renewal and has been characterized as an oncogene in neuronal stem cells and, paradoxically, as a tumour suppressor in epithelial tissues. How REST accomplishes these activities and how it is incorporated into cell signalling pathways is unclear.
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