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Research Highlights
Nature Reviews Cancer 8, 246–247 (1 April 2008) | doi:10.1038/nrc2362
Tumour suppressors: Spread your wings
Abstract
The Drosophila melanogaster Salvador (SAV)–Warts (WTS)–Hippo (HPO) pathway is a conserved tumour suppressor pathway that functions to regulate cell growth and apoptosis through inhibition of the downstream transcriptional co-activator Yorkie (YKI), the key targets of which include cyclin E, the microRNA bantam and Drosophila inhibitor of apoptosis 1 (diap-1, also known as th). Alain Zider and colleagues have now uncovered an additional oncogenic target of this pathway: the E2F1 transcription factor.
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