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Perspective
Nature Reviews Cancer 8, 309–316 (1 April 2008) | doi:10.1038/nrc2346
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
Abstract
The importance of multidisciplinary translational clinical trials is obvious; however, making them work is complex and challenging. Here I present an argument for designing and implementing multidisciplinary mechanistic trials and present the lessons our team at the Massachusetts General Hospital Cancer Center has learned from two such trials in cancer patients with locally advanced rectal carcinomas and recurrent glioblastomas.
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