Supplementary information

From the following article:

Integrative mathematical oncology

Alexander R. A. Anderson & Vito Quaranta

Nature Reviews Cancer 8, 227-234 (March 2008)

doi:10.1038/nrc2329

Supplementary information S1 (movie)

Tumour growth in a uniform ECM (cf. Figure 4a)
All of the 2 dimensional simulations show the spatio–temporal evolution of all four variables in a 1cm2 domain: tumour cells (upper left), proteinase (upper right), nutrient (lower left) and ECM (lower right) over a period of approximately 3 months. Cell colouration relates to either the tumour cell-cell adhesion status (low=blue, medium=cyan, high=yellow, very high=orange) or if the cell is dead (dark brown). Colouration of the other variables is done using the hot colourmap (high=white, medium=red, low=black) to represent varying concentrations. All parameters used in the simulations are identical with the exception of the different microenvironments.

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Supplementary information S2 (movie)

Tumour growth in a grainy ECM (cf. Figure 4b)
All of the 2 dimensional simulations show the spatio–temporal evolution of all four variables in a 1cm2 domain: tumour cells (upper left), proteinase (upper right), nutrient (lower left) and ECM (lower right) over a period of approximately 3 months. Cell colouration relates to either the tumour cell–cell adhesion status (low=blue, medium=cyan, high=yellow, very high=orange) or if the cell is dead (dark brown). Colouration of the other variables is done using the hot colourmap (high=white, medium=red, low=black) to represent varying concentrations. All parameters used in the simulations are identical with the exception of the different microenvironments.

Download Movie (5.27 KB)

Supplementary information S3 (movie)

Tumour growth under low nutrient conditions (cf. Figure 4c)
All of the 2 dimensional simulations show the spatio–temporal evolution of all four variables in a 1cm2 domain: tumour cells (upper left), proteinase (upper right), nutrient (lower left) and ECM (lower right) over a period of approximately 3 months. Cell colouration relates to either the tumour cell–cell adhesion status (low=blue, medium=cyan, high=yellow, very high=orange) or if the cell is dead (dark brown). Colouration of the other variables is done using the hot colourmap (high=white, medium=red, low=black) to represent varying concentrations. All parameters used in the simulations are identical with the exception of the different microenvironments.

Download Movie (827 KB)

Supplementary information S4 (movie)

A sequence of slices through the 3–dimensional tumour shown in Fig. 5. Colouration reflects different levels of cell density (green=low, red=high.)Each of the 3 dimensional simulations are simply different renderings of the same final tumour morphology after growth in a grainy ECM domain 0.5cm3 for approximately 1.5 months.

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Supplementary information S5 (movie)

A sequence of slices building up the 3–dimensional tumour shown in Fig. 5. Colouration is only used to try to distinguish different individual cells and has no other meaning.Each of the 3 dimensional simulations are simply different renderings of the same final tumour morphology after growth in a grainy ECM domain 0.5cm3 for approximately 1.5 months.

Download Movie (1.65 MB)

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