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Research Highlights
Nature Reviews Cancer 8, 162–163 (1 March 2008) | doi:10.1038/nrc2334
Tumour suppressors: One-hit wonder
Abstract
Cancer cells invariably refuse to sing to the tune of hypotheses that are composed by scientists to explain their behaviour and properties. The classical 'two-hit hypothesis' to explain the loss of tumour suppressor genes and cancer development is a fine example — the number of known haploinsufficient tumour suppressor genes is growing and Todd Golub and colleagues provide us with another example.
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