Abstract

Numerous components and pathways are involved in the complex interplay between cancer cells and their environment. The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein — small integrin-binding ligand N-linked glycoproteins (SIBLINGs) — are emerging as important players in many stages of cancer progression. From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.

Author affiliations

1. Metastasis Research Laboratory, University of Liege, Tour de Pathologie, -1, Bât. B23, Sart Tilman via 4000 Liège, Belgium.
2. Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912, USA.
3. National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda Maryland 20892–4320, USA.
4. Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA.

Correspondence to: Larry W. Fisher³ Email: lfisher@dir.nidcr.nih.gov

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