Abstract

Cancer research attracts broad resources and scientists from many disciplines, and has produced some impressive advances in the treatment and understanding of this disease. However, a comprehensive mechanistic view of the cancer process remains elusive. To achieve this it seems clear that one must assemble a physically integrated team of interdisciplinary scientists that includes mathematicians, to develop mathematical models of tumorigenesis as a complex process. Examining these models and validating their findings by experimental and clinical observations seems to be one way to reconcile molecular reductionist with quantitative holistic approaches and produce an integrative mathematical oncology view of cancer progression.

Author affiliations

1. Alexander R. A. Anderson is at the Division of Mathematics, University of Dundee, Dundee, DD1 4HN, Scotland, UK.
2. Vito Quaranta is at the Department of Cancer Biology, Vanderbilt University School of Medicine, 771 Preston Building, Nashville, Tennesee 37232–36840, USA.

Correspondence to: Alexander R. A. Anderson¹ Email: anderson@maths.dundee.ac.uk

Correspondence to: Vito Quaranta¹ Email: vito.quaranta@vanderbilt.edu

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