Review
Nature Reviews Cancer 8, 133-140 (February 2008) | doi:10.1038/nrc2296
Ral GTPases and cancer: linchpin support of the tumorigenic platform
Brian O. Bodemann1 & Michael A. White2 About the authors
Abstract
A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.
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Author affiliations
- Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
- Simmons Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Correspondence to: Michael A. White2 Email: michael.white@utsouthwestern.edu
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