Figures and Tables

From the following article:

Insulin and insulin-like growth factor signalling in neoplasia

Michael Pollak

Nature Reviews Cancer 8, 915-928 (December 2008)

doi:10.1038/nrc2536

Figure 1 - Insulin and insulin-like growth factor signalling in neoplasia

Figure 1

Timeline of key findings related to the roles of insulin and insulin-like growth factors (IGFs) in neoplasia.

Figure 2 - Insulin and insulin-like growth factor signalling in neoplasia

Figure 2

Key elements of insulin-like growth factor (IGF) signalling at the cellular and whole organism levels.

Figure 3 - Insulin and insulin-like growth factor signalling in neoplasia

Figure 3

Anti-ligand, anti-receptor and receptor tyrosine kinase inhibition approaches to targeting.

Figure 4 - Insulin and insulin-like growth factor signalling in neoplasia

Figure 4

An example of an objective response to monotherapy with an insulin-like growth factor 1 receptor (IGF1R)-specific antibody.

Figure 5 - Insulin and insulin-like growth factor signalling in neoplasia

Figure 5

Endocrine response to IGF1R blockade.

Figure 6 - Insulin and insulin-like growth factor signalling in neoplasia

Figure 6

Metformin actions that are relevant to neoplasia.