Abstract

RNA polymerase III (Pol III) makes a variety of small non-coding RNAs, such as tRNA and 5S ribosomal RNA. Increased expression of pol III products is often observed in transformed cells. Much progress has been made in determining how Pol III-dependent transcription is regulated and how it increases in cancers, but the importance of this increase has not been clearly established. New evidence suggests that Pol III output can substantially affect transformation.

Author affiliations

1. Robert J. White and Lynne Marshall are at the Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD and the Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

Correspondence to: Robert J. White¹ Email: r.white@beatson.gla.ac.uk

Published online 6 November 2008

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