Table of contents
From the editors
p825 | doi:10.1038/nrc2535
Research Highlights
Immunology: An unexpected complement | PDF (140 KB)
p827 | doi:10.1038/nrc2531
Angiogenesis: Multipotent tumour endothelial cells | PDF (154 KB)
p828 | doi:10.1038/nrc2526
Metastasis: A sweet sabre promotes cell invasion | PDF (129 KB)
p828 | doi:10.1038/nrc2532
Trial Watch
Inhibiting survivin | Prenatal environment and breast cancer risk | PDF (144 KB)
p828 | doi:10.1038/nrc2534
Tumorigenesis: Keeping a watchful eye | PDF (145 KB)
p829 | doi:10.1038/nrc2530
Radiotherapy: Worming your way to cell death | PDF (146 KB)
p830 | doi:10.1038/nrc2533
In the news
Vitamin C: friend or foe? | PDF (102 KB)
p830 | doi:10.1038/nrc2537
In brief
Tumorigenesis | Genomic instability | Cell cycle | Signalling | PDF (127 KB)
p831 | doi:10.1038/nrc2538
Metastasis: Preparing the soil | PDF (145 KB)
p832 | doi:10.1038/nrc2525
Tumorigenesis: It's a knockout! | PDF (146 KB)
p832 | doi:10.1038/nrc2527
Genetics: ALK takes the rap | PDF (125 KB)
p833 | doi:10.1038/nrc2529
Reviews
Derailed endocytosis: an emerging feature of cancer
Yaron Mosesson, Gordon B. Mills & Yosef Yarden
p835 | doi:10.1038/nrc2521
Oncogenic alteration of the endocytic machinery is a hallmark of cancer. As reviewed here, these alterations can lead to changes in morphology, polarity, motility, adhesion and growth factor-activated signalling pathways.
See also: Correspondence by Wu & Hirsch | Correspondence by Mosesson et al.
Article series: Hypoxia and metabolism
Hypoxia signalling through mTOR and the unfolded protein response in cancer
Bradly G. Wouters & Marianne Koritzinsky
p851 | doi:10.1038/nrc2501
Responses to hypoxia are orchestrated not only through activation of the hypoxia–inducible factor family of transcription factors (HIFs), but also through HIF–independent signalling pathways. How are these pathways integrated?
Article series: Hypoxia and metabolism
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
William G. Kaelin Jr
p865 | doi:10.1038/nrc2502
Deregulation of hypoxia-inducible factor (HIF) is an established feature of tumours that develop in patients with von Hippel–Lindau disease, caused by inactivating germline mutations of the VHL tumour suppressor gene. However, HIF-independent activities of VHL also seem to be important for the pathogenesis of the disease.
Perspectives
Opinion
Ageing, oxidative stress and cancer: paradigms in parallax
Christopher C. Benz & Christina Yau
p875 | doi:10.1038/nrc2522
Ageing is thought to be associated with increased oxidative stress and increased cancer risk. However, recent evidence that breast cancers arising in older women are not associated with oxidative stress questions the link between age and increasing oxidative stress. Does ageing cause or simply permit cancer development?
Opinion
VEGF-A splicing: the key to anti-angiogenic therapeutics?
Steven J. Harper & David O. Bates
p880 | doi:10.1038/nrc2505
Recent data indicates an anti-angiogenic function for a new class of VEGF-A isoforms. In this Opinion article, Steven Harper and David Bates discuss the emerging role of these proteins in tumourigenesis and anti-angiogenic therapeutic strategies.
Opinion
Cytokines and their relationship to the symptoms and outcome of cancer
Bostjan Seruga, Haibo Zhang, Lori J. Bernstein & Ian F. Tannock
p887 | doi:10.1038/nrc2507
In patients with advanced cancer, pro-inflammatory cytokines are associated with anorexia and cachexia, pain, fatigue, depression, toxicity of treatment and resistance to treatment. What is our current understanding of the pathways that mediate these effects and how can we prevent them?
See also: Correspondence by Molfino et al.
