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Nature Reviews Cancer 8, 833 (1 November 2008) | doi:10.1038/nrc2529

Genetics: ALK takes the rap

Nicola McCarthy

Like retinoblastoma, neuroblastoma can be an inherited or a sporadic tumour but, unlike retinoblastoma, the genetics underlying neuroblastoma development have remained for the most part enigmatic. Four papers published in Nature have now found at least one major culprit — the anaplastic lymphoma kinase (ALK).