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Research Highlights
Nature Reviews Cancer 8, 735 (1 October 2008) | doi:10.1038/nrc2517
Therapy: Developmental parallels
Abstract
Numerous epithelial cancers are reported to be reliant on ligand-dependent Hedgehog (Hh) signalling, providing a rationale for the development of Hh inhibitors. However, physiological Hh signalling is mediated in many tissues through paracrine effects on mesenchymal cells.
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