Perspectives
Nature Reviews Cancer 8, 799-806 (October 2008) | doi:10.1038/nrc2500
Opinion: Replication licensing and cancer — a fatal entanglement?
J. Julian Blow1 & Peter J. Gillespie1 About the authors
Abstract
Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under- or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.
Author affiliations
- J. Julian Blow and Peter J. Gillespie are at the Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee, DD1 5EH, UK.
Correspondence to: J. Julian Blow1 Email: j.j.blow@dundee.ac.uk
Published online 29 August 2008
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