Perspectives
Nature Reviews Cancer 7, 713-722 (September 2007) | doi:10.1038/nrc2211
Opinion: Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state
Kelly A. Green1 & Jason S. Carroll1 About the authors
Abstract
Oestrogen receptor-
(ER)-regulated transcription in breast cancer cells involves protein co-factors that contribute to the regulation of chromatin structure. These include co-factors with the potential to regulate histone modifications such as acetylation or methylation, and therefore the transcriptional state of target genes. Although much of the information regarding the interaction of specific co-factors with ER has been generated by studying specific promoter regions, we now have an improved understanding of the nature of these interactions and are better placed to relate these with ER activity and potentially with the activity of breast cancer drugs, including tamoxifen.
Author affiliations
- Kelly A. Green and Jason S. Carroll are at the Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK.
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