Review
Nature Reviews Cancer 7, 684-700 (September 2007) | doi:10.1038/nrc2196
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
Kristin K. Deeb1, Donald L. Trump2 & Candace S. Johnson1 About the authors
Abstract
Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers. Preclinical research indicates that the active metabolite of vitamin D, 1
,25(OH)2D3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. In addition, 1
,25(OH)2D3 potentiates the anticancer effects of many cytotoxic and antiproliferative anticancer agents. Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1
,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents.
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Author affiliations
- Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, USA.
- Departments of Pharmacology and Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA.
Correspondence to: Candace S. Johnson1 Email: candace.johnson@roswellpark.org
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