Review
Nature Reviews Cancer 7, 654-658 (September 2007) | doi:10.1038/nrc2192
Maximizing mouse cancer models
Kristopher K. Frese1 & David A. Tuveson1 About the authors
Abstract
Animal models of cancer provide an alternative means to determine the causes of and treatments for malignancy, thus representing a resource of immense potential for cancer medicine. The sophistication of modelling cancer in mice has increased to the extent that investigators can both observe and manipulate a complex disease process in a manner impossible to perform in patients. However, owing to limitations in model design and technology development, and the surprising underuse of existing models, only now are we realising the full potential of mouse models of cancer and what new approaches are needed to derive the maximum value for cancer patients from this investment.
- View At a Glance
Author affiliations
- Cambridge Research Institute, Cancer Research UK and University of Cambridge Department of Oncology, Cambridge, CB2 0RE, UK.
Correspondence to: David A. Tuveson1 Email: david.tuveson@cancer.org.uk
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Combined therapeutic strategy using erythropoietin and mesenchymal stem cells potentiates neurogenesis after transient focal cerebral ischemia in ratsJournal of Cerebral Blood Flow & Metabolism Original Article
Normal levels of immunocompetence in possums (Trichosurus vulpecula) exposed to different laboratory housing conditions post captureImmunology and Cell Biology Brief Communication
Normal levels of immunocompetence in possums (Trichosurus vulpecula) exposed to different laboratory housing conditions post captureImmunology and Cell Biology Brief Communication
Optical coherence tomography for ultrahigh resolution in vivo imagingNature Biotechnology Research (01 Nov 2003)
