MicroRNA: Another piece in the p53 puzzle | PDF (98 KB)

p488 | doi:10.1038/nrc2178

DNA repair: The big and the small picture | PDF (197 KB)

p489 | doi:10.1038/nrc2176

Tumour supressor: Surviving the tumour suppressor | PDF (126 KB)

p490 | doi:10.1038/nrc2179

Cancer stem cells: Fishing for clues | PDF (190 KB)

p490 | doi:10.1038/nrc2181

Chemotherapeutics: Lethal and resistant partners | PDF (105 KB)

p491 | doi:10.1038/nrc2183

Leukaemia: Reduction increases risk | PDF (118 KB)

p492 | doi:10.1038/nrc2182

Genomics: Finding needles in a haystack | PDF (225 KB)

p493 | doi:10.1038/nrc2177

Endometrial cancer: Another tyrosine kinase target? | PDF (117 KB)

p494 | doi:10.1038/nrc2180

CDC25 phosphatases in cancer cells: key players? Good targets?

Rose Boutros, Valérie Lobjois & Bernard Ducommun

p495 | doi:10.1038/nrc2169

Cell division cycle 25 (CDC25) phosphatases regulate key cell-cycle transitions. Thus, it is not surprising that CDC25 overexpression has been reported in a significant number of human cancers. What are the roles of CDC25 phosphatases in abnormal cell proliferation, and what is the future for targeting CDC25 activity in cancer treatment?

• Abstract
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• PDF (584 KB)

Assessing intraepithelial neoplasia and drug safety in cancer-preventive drug development

Gary J. Kelloff & Caroline C. Sigman

p508 | doi:10.1038/nrc2154

Can the process of new cancer-preventive drug development be improved by focusing on precancer (intraepithelial neoplasia) to better identify subjects at risk and prove efficacy in shorter, smaller trials?

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• PDF (423 KB)

Calcium and cancer: targeting Ca²⁺ transport

Gregory R. Monteith, Damara M^cAndrew, Helen M. Faddy & Sarah J. Roberts-Thomson

p519 | doi:10.1038/nrc2171

Altered expression of specific Ca²⁺ channels and pumps are characterizing features of some cancers. The ability of Ca²⁺ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. Which Ca²⁺ channels and pumps should be targeted and what strategy should be used?

• Abstract
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Gene methylation and early detection of genitourinary cancer: the road ahead

Paul Cairns

p531 | doi:10.1038/nrc2170

Inactivation of cancer-relevant genes through DNA methylation is a common event in tumours, including genitourinary cancers. The clinical implementation of gene methylation screenings could provide a new avenue for the early detection of genitourinary cancers, which are increasing worldwide. What are the current challenges?

• Abstract
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