Progress
Nature Reviews Cancer 7, 409-413 (June 2007) | doi:10.1038/nrc2145
Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation
Leonardo Salmena1 & Pier Paolo Pandolfi1 About the authors
Abstract
Recent studies have shown that three major tumour-suppressor proteins undergo monoubiquitylation-mediated nuclear–cytoplasmic shuttling. Importantly, this mechanism has consequences for cancer and implies that proper localization is central to the function of tumour suppressors. This Progress article highlights recent efforts demonstrating that monoubiquitylation coupled to nuclear–cytoplasmic shuttling might be a novel regulatory mechanism that directly influences the function of tumour suppressors.
Author affiliations
- Leonardo Salmena and Pier Paolo Pandolfi are at the Cancer Biology and Genetics Program and Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Correspondence to: Pier Paolo Pandolfi1 Email: p-pandolfi@ski.mskcc.org
Published online 17 May 2007
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