Abstract

PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and so affect protein function and/or stability. PIN1 regulates a number of proteins important for cell-cycle progression and, based on gain- and loss-of-function studies, is presumed to operate as a molecular timer of this important process. Therefore, it seems logical that alterations in the level of PIN1 can influence hyperproliferative diseases such as cancer. However, the precise role of PIN1 in cancer remains controversial.

Author affiliations

1. Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, 4th floor BRB II/III 421 Curie Boulevard, Philadelphia, Pennsylvania 19104–6160, USA.
2. Department of Pharmacology and Cancer Biology, C238 Levine Science Research Center, PO BOX 3813, Duke University Medical Center, Durham, North Carolina 27710, USA.

Correspondence to: Anthony R. Means² Email: means001@mc.duke.edu

Published online 5 April 2007

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