Review
Nature Reviews Cancer 7, 246-255 (April 2007) | doi:10.1038/nrc2108
Reprogramming metastatic tumour cells with embryonic microenvironments
Mary J. C. Hendrix1, Elisabeth A. Seftor1, Richard E. B. Seftor1, Jennifer Kasemeier-Kulesa2, Paul M. Kulesa2 & Lynne-Marie Postovit1 About the authors
Abstract
Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration
- View At a Glance
Author affiliations
- Cancer Biology and Epigenomics Program, Children's Memorial Research Centre, Robert H. Lurie Comprehensive Cancer Centre, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA.
- Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Correspondence to: Mary J. C. Hendrix1 Email: mjchendrix@childrensmemorial.org
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressivenessNature Medicine Article (01 Aug 2006)
Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cellsNature Biotechnology Research
Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cellsNature Biotechnology Research