Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Review
Nature Reviews Cancer 7, 182–191 (1 March 2007) | doi:10.1038/nrc2070
The Salvador|[ndash]|Warts|[ndash]|Hippo pathway |[mdash]| an emerging tumour-suppressor network
&
Abstract
Intense research over the past four years has led to the discovery and characterization of a novel signalling network, known as the Salvador–Warts–Hippo (SWH) pathway, involved in tissue growth control in Drosophila melanogaster. At present, eleven proteins have been implicated as members of this pathway, and several downstream effector genes have been characterized. The importance of this pathway is emphasized by its evolutionary conservation, and by increasing evidence that its deregulation occurs in human tumours. Here, we review the main findings from Drosophila and the implications that these have for tumorigenesis in mammals.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
